Laparoscopic Associating Liver Partition With Portal Vein Ligation for Staged Hepatectomy (ALPPS) for Colorectal Liver Metastases (CRLM)

Inclusion criteria

• Male or female subjects > 18 years < 75 of age.
• ECOG performance status 0-1.
• Histologically confirmed colorectal adenocarcinoma.
• Imaging (CT or MRI) or pathological confirmation of liver metastasis.
• Child-Pugh grade A liver function.
• FLR/sTLV (standardized total liver volume) < 30% (patients without underlying liver diseases)or < 40% (patients with liver diseases, such as hepatic steatosis, cirrhosis, or liver damage after chemotherapy).
• The indication of surgery is evaluated by a multidisciplinary team attended by hepatobiliary surgeons, oncologists, hepatologists and radiologists.

Exclusion criteria

• Patients with unresectable extrahepatic metastatic disease (except potentially resectable lung metastases) or primary tumor.
• Patients with severe concomitant diseases who are intolerance of major liver surgery by the judgment of the surgeon.
• Diagnosis of other malignant tumors within the past 5 years.
• Intention to become pregnant during the course of the study.
• Inability to comply with the study protocol.
• Previous enrollment in the current study.