The Role of CircDENND4C in Epithelial Ovarian Cancer

circular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNAs [8], are involved in the regulation of various biological functions. They act by sponging off certain microRNAs (miRNAs) and play a role in the pathogenesis of many diseases, including cancers [9-11]. In addition, circRNAs are not com- monly degraded by RNA enzymes present in body flu- ids [8], and most of them possess expression specificity at the tissue, cell, and developmental stage level [12,13]. Thus, they can be ideal clinica

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Key information

Conditions

Ovarian Cancer Adnexal Diseases Endocrine Gland Neoplasms Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Gonadal Disorders Neoplasms Neoplasms by Site Ovarian Diseases Ovarian Neoplasms Urogenital Diseases Urogenital Neoplasms

Age range

18 year–75 year

Sex eligibility

Female

Study type

Observational

About this study

epithelial OC (EOC), the most common form of OC, accounts for 90% of all OC cases [2]. EOC has the highest mortality among all gynecologic tumors and poses a serious threat to women's life [3].herefore, early clinical diagnosis is crucial. Commonly used laboratory indicators for OC diagnosis

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients at South Egypt Cancer institute and Recently diagnosed ovarian cancer patients 2. Patients not went to surgery.

Exclusion criteria

. Patients receive any anti-cancer therapy. 2. Patients diagnosed with other concomitante cancer or chronic disease

Treatment and study plan

Primary outcomes

role of circDENND4c in the diagnosis of ovarian cancer

Time frame: baseline

by quality real time PCR we use the circDENND4c as a tumour marker for ovarian cancer

Study contacts

Contact information is provided by the study sponsor or research team.

Marwa MamDouh Mohamed

CONTACT

[email protected]

20+1153538300

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2028
Study completion: 2028
First posted: Sep 27, 2024
Registry last updated: Sep 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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