The goal of this clinical trial is to test the feasibility, behavioral/neural mechanisms, and preliminary efficacy of "MINDfulness-based Substance Use Prevention Program," or "MINDS-UP", a novel substance use prevention meditation intervention for children and adolescents between the ages of 10 and 14. The aims of the study are:
Aim 1: Determine feasibility and acceptability of MINDS-UP as a preventive intervention via a) retention, b) attendance, c) teacher-rated participation, d) student-rated participation, e) homework completion, and f) acceptability.
Aim 2: Evaluate neuropsychological mechanisms (target engagement) of MINDS-UP.
Aim 3 (Exploratory): Assess preliminary efficacy of MINDS-UP on substance use initiation (SUI).