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NCT Number: NCT06512129

Defining Volume Status in Sepsis With Extracellular Water Measurement

The goal of this observational study is to learn about the influence of extracellular water on volume status in adult sepsis patients presenting with hemodynamic instability. The main question it aims to answer is:

• Can measurement of extracellular water (MoistureMeterD, Delfin Technologies Ltd, Kuopio, Finland) contribute to the description of hemodynamic instability in adult sepsis patients.

Patients with sepsis admitted to intensive care will receive standard care with the addition of measurement of extracellular water.

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Key information

Conditions

Sepsis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Adult patients with sepsis admitted to any of our ICUs will be recruited. During the first three days after inclusion blood samples and extended non-invasive monitoring, including monitoring of the microcirculation (CytoCam) and measurement of extracellular water (dielectronic constant), will be added to routine care and monitoring.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults with sepsis.

Exclusion criteria

  • Pregnancy, other than sepsis known cause of shock.

Treatment and study plan

Primary outcomes

  1. Phenotypes in sepsis - extracellular water for volume status characterization.

    Time frame: 7 days

    Can measurement of extracellular water (MoistureMeterD, Delfin Technologies Ltd, Kuopio, Finland) contribute to the description of hemodynamic instability in adult sepsis patients during the first 72 hours?

Study contacts

Contact information is provided by the study sponsor or research team.

Annelie Barrueta Tenhunen, MD, PhD

CONTACT

[email protected]

+46728881882

Sponsors and collaborators

Lead sponsor

Uppsala University

Other

Registry information

Official study title

Phenotypes in Sepsis - Extracellular Water for Volume Status Characterization

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jul 22, 2024
Registry last updated
Jan 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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