Lemborexant on Improving Sleep Quality Among Hospital Rotating Shift Workers

Inclusion criteria

• Age 20-60 years
• Rotating shift workers at least 3 months and continue rotating shift until end of study
• Participants who have sleep problem especially total sleep time lower than 6 hours and/or unable to sleep effectively according to the ICSD-3 at least 1 criteria
• Participants who have sleepy while working and have Epworth sleepiness scale in shift grater than or equal to 10 points

Exclusion criteria

• Receiving drug interaction esp. drugs induced CYP3A4 (moderate to severe) or drugs inhibited CYP3A4 (moderate to severe)
• Untreatment mental health disease or in process medication adjustment
• Hepatic function in Chid-Pugh C
• Pregnancy
• Breastfeeding
• Participants who in process medication adjustment such as mental heat, neurology, insomnia, contraceptive drugs.
• Diagnosis obstructive sleep apnea (OSA) with or without CPAP using or diagnosis restless leg syndrome or circadian rhythm disorders or narcolepsy
• Complex sleep behaviors such as sleep driving, sleep phone, sleep cooking
• HAM-D grater than or equal to 24 points
• HAM-A grater than or equal to 24 points
• Caffeine taking grater than 400 mg/day or can't not hold caffeine 4 hours before bedtime
• Substance abuse or alcoholism within 2 years ago
• Alcohol intake grater than 140 g of alcohol per week in female or intake grater than 210 g of alcohol per week in male or can't control alcohol drinking greater than 20 g of alcohol per day or can't hold alcohol within 3 hours before bedtime
• Cannabinoid using within 1 week ago
• Participants who have underlying disease such as stroke, atrial fibrillation, chronic obstructive pulmonary disease, hepatic impairment, severe renal impairment, cognitive impairment, cancer, chronic pain
• Participant who use of benzodiazepine or non-benzodiazepine in treatment of insomnia
• Participant who have nocturia problem
• Participant who have mental health problem which the physician conclude it affect the safety of participant
• Participant who have suicidal thinking with or without plan or have suicidal behaviors within 10 years ago
• Participant who have major surgery schedule during the study
• Travel across greater than 3 time zone within 2 weeks before include participant
• Allergy of lemborexant or component of lemborexant
• Have previously participated in study that used lemborexant
• Participant who