DAO DEFICIENCY SCREENING AMONG PATIENTS WITH INSOMNIA SYMPTOMS

Insomnia is prevalent in the global population. Diamino oxidase (DAO) is an enzyme that degrades histamine. When there is not enough DAO enzyme activity in the body, histamine accumulates and it can lead to symptoms in the nervous system, among others. In this study we wanted to study the prevalence of DAO deficiency in pacients with insomnia symptoms.

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Key information

Conditions

Insomnia Dyssomnias Insomnia Disorder Mental Disorders Nervous System Diseases Sleep Disorders, Intrinsic Sleep Initiation and Maintenance Disorders Sleep Wake Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

AdSalutem Sleep Institute

Barcelona, 08008, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Older than 18 years old
With one or more symptoms of insomnia
Explicit acceptance to participate to the study through informed consent

Exclusion criteria

Insomnia symptoms that could be justified by the existance of another sleep pathology (e.g., narcolepsy)

Treatment and study plan

Primary outcomes

number of patients with insomnia symptoms and DAO deficiency

Time frame: at the time of enrollment

number (absolute and percentage) of patients with insomnia symptoms and DAO deficiency

Interested in participating?

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Sponsors and collaborators

Lead sponsor

AB Biotek

Industry

Registry information

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2023
First posted: Jul 5, 2024
Registry last updated: May 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed