Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06430346

Exercise Prehabilitation for Locoregional Esophageal Cancer

The purpose of the study is to examine the feasibility and acceptability of exercise "prehabilitation" for patients preparing for esophageal cancer resection (removal).

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Esophageal Cancer Digestive System Diseases Digestive System Neoplasms Esophageal Diseases Esophageal Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Head and Neck Neoplasms Neoplasms Neoplasms by Site

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Moffitt Cancer Center

Tampa, Florida, 33612, United States

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Biopsy-proven locoregional esophageal cancer (LEC)
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • Treatment plan including neoadjuvant chemoradiation therapy and surgical resection
  • Ability to read and speak English

Exclusion criteria

  • Regular engagement in resistance training (2x/week targeting all major muscle groups)
  • Screen failure for exercise safety based on PAR-Q
  • Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
  • Recent fracture or acute musculoskeletal injury that precludes ability to participate in resistance training safely
  • Numeric pain rating scale of 7 or more out of 10
  • Myopathic or rheumatologic disease that impacts physical function

Treatment and study plan

Exercise

Behavioral

Physical activity and resistance training

Primary outcomes

  1. Retention

    Time frame: Up to 11 weeks

    The number of participants who complete T0 and T1 measures.

Secondary outcomes

  1. Exploratory outcomes and changes

    Time frame: Up to 17 weeks

    The number of participants who demonstrate improvements in exploratory outcome measures.

  2. Clinical and treatment outcomes

    Time frame: Up to 17 weeks

    Chi-square testing will be used to determine if there's a difference in perioperative outcomes between groups.

Interested in participating?

Recruiting

Interested in participating?

Request Info

Sponsors and collaborators

Lead sponsor

H. Lee Moffitt Cancer Center and Research Institute

Other

Registry information

Official study title

Exercise Prehabilitation for Locoregional Esophageal Cancer: A Pilot Study

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
May 28, 2024
Registry last updated
Dec 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.