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OpenTrials
Completed

NCT Number: NCT06413199

Adaptive Response of Brain Towards Resistance Training in Healthy Individuals

The novelty of this study is to identify the mechanism of nervous system by applying resistance training intervention in healthy individuals.

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Key information

Conditions

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

PSRD Hospital

Lahore, Punjab Province, 54000, Pakistan

About this study

Resistance training is a form of exercise that is popular particularly for its role in improving athletic performance by increasing muscular strength, power and speed, hypertrophy, local muscular endurance, motor performance, balance and coordination. The objective of the study is to find out the effects of resistance training on Central and Peripheral Nervous System in healthy individuals. A total of 100 participants will be included in the study including both male and female. The study will be divided into two main groups. Experimental group will perform 8-12 Reps with 1.5 sec concentric and 1.5 sec eccentric contraction of bench press with 90 sec of rest between sets with 2 sets per week for 2 months.

1RM of control group will be calculated through the same method and the training protocol for the Control group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts. The load was progressively increased each attempt to try to reach or exceed their previous 1RM.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Body Mass Index should be 18.5-24.9 kg/m2.
  • Participants were untrained and had not engaged in resistance exercise within 6 months prior to beginning the study.

Exclusion criteria

  • Participants with any kind of Gastrointestinal Tract disturbance will be excluded from the study.
  • Participants with any kind of Musculoskeletal injury will be excluded from the study.
  • Participant with any kind of Neurological disturbance will be excluded from the study.
  • Participants who use tobacco products within the previous 6 months.
  • Participants who take any type of medication within the previous 6 months.

Treatment and study plan

Hyper Training

Other

Experimental group will perform 2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, 4 sets with a goal of 8-12 Reps with 90 seconds rest between sets. 1.5 second concentric and 1.5 second eccentric contraction of bench press, The elbows had to be fully locked out to be counted as a repetition.

1 Repetition maximum training group

Other

2 training session per week for 8 weeks, 1 set of 10 unloaded repetitions in arms as a warm-up, 1 Repetition maximum training group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts, the load was progressively increased each attempt to try to reach or exceed their previous 1 repetition maximum.

Primary outcomes

  1. NCS (Motor Nerve Conduction Study)

    Time frame: • 0 week • 8th week

    To determine how fast or slow the nerves are conducting an electrical current using F wave

  2. EEG (Electroencephalography)

    Time frame: • 0 week • 8th week

    To measure the electrical activity of the brain using alpha and beta waves

  3. Dynamometer

    Time frame: • 0 week • 4th week • 8th week

    To measure the strength after resistance training

  4. Estimation of Albumin & Globulin ratio

    Time frame: • 0 week • 8th week

    To measure the total amount of protein in blood and effects of resistance training

Sponsors and collaborators

Lead sponsor

Pakistan Society for Rehabilitation of Differently Abled Hospital

Other

Collaborators

  • University of Karachi

Registry information

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
May 14, 2024
Registry last updated
Sep 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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