Study of the Location of Motor Cortical Stimulation Electrodes in Chronic Neuropathic Refractory Patients

Cortical stimulation has been used since 1991 to treat neuropathic pain. However, the underlying mechanisms are still incompletely understood and under-studied. In this protocol, the investigators aim to study the myeloarchitectonic and functional characteristics of areas activated by cortical epidural electrodes and to determine their relation to therapy response in chronic neuropathic refractory pain patients.

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Key information

Conditions

Neuropathic Pain Nervous System Diseases Neuralgia Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU NICE

Nice, Alpes Maritimes, France

Location status: Recruiting

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adults
patient implanted with a motor cortical stimulation system for chronic neuropathic refractory pain,
patient with available postoperative scanner

Exclusion criteria

None

Treatment and study plan

Primary outcomes

Pourcentage of pain relief

Time frame: 1 year

percentage of pain relief for different stimulated areas

Secondary outcomes

location of leads on the postoperative imaging

Time frame: 1 month

location of leads on the postoperative imaging

Interested in participating?

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Interested in participating?

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Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2025
Study completion: 2027
First posted: Jan 22, 2024
Registry last updated: Jun 29, 2026

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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