Impact of Perioperative Body Composition Abnormalities on Patient Outcomes After Liver Transplantation

Accumulating evidence suggests the prognostic significance of body composition in chronic diseases and neoplastic diseases. CT imaging-based body composition abnormalities are significantly associated with post-LT adverse outcomes including decreased quality of life (QOL), impaired graft regeneration and mortality. However, the perioperative changes in body composition and their potential clinical implications remain unexplored. The objective of this study is to systematically explore and clarify the correlation between body composition and the prognosis of liver transplant patients through dynamic peri-transplant mornitoring.

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Key information

Conditions

Liver Transplantation Body Composition

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients undergoing deceased donor liver transplantation (DDLT) for the first time.

Exclusion criteria

Pediatric transplants
Re-transplants
Multi-organ transplants
Liver cancer patients with macrovascular invasion or distant metastasis
Patients who died within 30 days after transplantation

Treatment and study plan

Primary outcomes

Postoperative mortality

Time frame: 2015.1.1-2022.12.31
Postoperative recurrence of liver cancer

Time frame: 2015.1.1-2022.12.31

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Sponsors and collaborators

Lead sponsor

Zhejiang University

Other

Collaborators

First Affiliated Hospital of Zhejiang University
Shulan (Hangzhou) Hospital
The Affiliated Hospital of Qingdao University

Registry information

Important dates

Study start: 2015
Primary completion: 2022
Study completion: 2022
First posted: Jan 17, 2024
Registry last updated: Jan 17, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed