RESTORE-TAVI Pilot

Average number of patients per month willing to give informed consent and be randomised into a trial of a perioperative frailty intervention

In-hospital adverse events (e.g. falls, ischaemia, arrhythmia, acute kidney injury), in-hospital mortality

defined as loss of ≥ 1 ADL at discharge compared to admission; and followed-up at 30 days after discharge

Assessed daily during hospitalisation by using 4AT until the seventh day post-TAVI and then twice weekly thereafter

Measured using EQ-5D-5L at baseline and 30 days post discharge via telephone

By comparing SARC-F (strength, assistance with walking, rise form a chair, climb stairs and falls) questionnaire at baseline and 30 days (via telephone) after discharge

By comparing dominant handgrip strength at admission and discharge - average of 3 trials of maximal isometric grip measured in kilograms using a Jamar hydraulic hand dynamometer (Anatomy Supply Partners LLC, Georgia, USA).

By comparing timed chair rises at admission and discharge - time (measures in seconds) to complete five chair rises without using arms.

Assessed using T-MoCA at admission and 30 days post discharge via telephone

Assessed using HADS at admission and 30 days post discharge via telephone

Duration of inpatient stay at tertiary centre

e.g. to patient's own home, long-term care facility or district general hospital

Measured at 30 days post discharge from tertiary centre using hospital records and patient telephone-interview

Measured at 30 days post discharge using hospital records and NHS Spine database