Application of Serum Bile Acid Profile in the Diagnosis of Gastric Cancer

Inclusion criteria

• Age between 18-70, both gender;
• The gastric cancer group was early gastric cancer or advanced gastric cancer diagnosed by endoscopic examination and pathological biopsy. The non-gastric cancer group included patients without gastric lesions, superficial gastritis, chronic atrophic gastritis, intestinal metaplasia or dysplasia diagnosed by gastroscopy or pathological biopsy;
• Informed consent was obtained.

Exclusion criteria

• The patients have diseases that affect bile acid metabolism, such as liver cirrhosis, gallstones or inflammatory bowel disease, Behcet's disease, etc;
• Due to other diseases, the patient took drugs affecting bile acid metabolism, such as cholestyramine, anti-inflammatory Lidan tablets, Danshu capsules, ursodeoxycholic acid, obticholic acid, Schisandrin B, tanshinone ⅡA, Yinzhihuang, etc;
• Pregnant women;
• Primary tumors of other systems were diagnosed;
• Those with poor physiopathological conditions, such as chronic kidney disease requiring long-term dialysis;
• Patients with mental illness;
• Patients who have received radiotherapy or surgery previously;
• Those with poor adherence or difficult to follow up.