PET-CT Predicting Lymph Nodes Metastasis

This study is a single-center prospective clinical study that aims to evaluate the predictive value of preoperative 18F-FDG-PET-CT and 18F-FAPI-PET/CT for lymph node metastasis in patients with non-small cell lung cancer. The final pathological results were used to assess the predictive value of PET-CT for lymph node metastasis.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Non Small Cell Lung Cancer Bronchial Neoplasms Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Lung Diseases Lung Neoplasms Lymph Node Metastasis Lymphatic Metastasis Neoplasm Metastasis Neoplasms Neoplasms by Site Neoplastic Processes Pathologic Processes Pathological Conditions, Signs and Symptoms Positron Emission Tomography Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Shanghai Cancer Center

Shanghai, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Solitary tumor, or multiple tumors with only ground-glass nodules (GGNs) apart from the primary lesion.
Diameter of the primary lesion ≤5cm, with a CTR between 0.5 and 1.
Pathological confirmation of non-small cell lung cancer (NSCLC) either before or during surgery.
No prior radiotherapy or chemotherapy for initial treatment.
No history of malignant tumors.

Exclusion criteria

Locally advanced or distant metastasis.
Pleural dissemination observed during surgery.
History of malignant tumors.
Received neoadjuvant therapy.
Histopathological examination reveals lung malignancies other than non-small cell lung cancer (NSCLC).

Treatment and study plan

Primary outcomes

Predictive value of 18F-FDG-PET/CT and 18F-FAPI-PET/CT for lymph node metastasis

Time frame: from enrollment to 1 month after surgery

Sponsors and collaborators

Lead sponsor

Fudan University

Other

Registry information

Official study title

The Value of PET-CT in Predicting Lymph Nodes Metastasis in Non Small Cell Lung Cancer

Important dates

Study start: 2023
Primary completion: 2026
Study completion: 2026
First posted: Aug 1, 2023
Registry last updated: Mar 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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