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OpenTrials
Completed

NCT Number: NCT05965908

Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome

The aim of this study is to compare the hormonal, metabolic and clinical effects of metformin and liraglutide in infertile women with PCOs.

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Key information

Conditions

Polycystic Ovary Adnexal Diseases Cysts Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Gonadal Disorders Neoplasms Ovarian Cysts Ovarian Diseases Polycystic Ovary Syndrome Urogenital Diseases

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 3

Primary location

Beni-suef university Hospital

Banī Suwayf, Beni Suweif Governorate, 62521, Egypt

About this study

This prospective randomized clinical trial will be conducted at Gynecology and obstetrics department in Beni Suef University Hospital, Beni suef, Egypt.

The trial will be included 150 women with Poly cystic ovary syndrome based on the Rotterdam criteria.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women aged 18-45 years
  • Poly cystic ovary syndrome based on the Rotterdam criteria

Exclusion criteria

  • congenital adrenal hyperplasia,
  • poorly controlled thyroid disease
  • Taking antidiabetic drugs which can affect insulin resistance
  • chronic kidney disease
  • liver dysfunction (AST or ALT
  • Documented use of oral hormonal contraceptives and hormone-releasing implants
  • intolerance or allergy to liraglutide or metformin

Treatment and study plan

liraglutide

Drug

glucagon-like peptide 1 receptor agonist

Other names: saxenda ampoules

metformin

Drug

biguanide antihyperglycemic

Other names: Glucophage 1000mg

Primary outcomes

  1. Insulin Resistance (HOMA-IR)

    Time frame: 6-months

Sponsors and collaborators

Lead sponsor

Beni-Suef University

Other

Registry information

Official study title

Effect of Liraglutide on Different Parameters (Clinical , Metabolic and Hormonal) in Obese Women With Polycystic Ovary Syndrome

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jul 28, 2023
Registry last updated
Aug 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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