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NCT Number: NCT05922969

Safety of Low PEEP Maneuvers During ARDS Management

Acute Respiratory distress syndrome (ARDS) is a severe condition in which protective ventilation is a critical point in its management. Positive end expiratory pressure (PEEP) setting can be challenging for clinicians and high PEEP has been associated with better outcome in moderate and severe ARDS. Recently, recruitment to inflation ratio and airway closure have been investigated in order to help PEEP adjustment. However, ventilatory maneuvers are performed with a low level of PEEP and therefore expose to derecruitment and oxygen desaturation. So far, the risk of oxygen desaturation has not been investigated and risk factors are unknown.

The aim of this study is to evaluate the prevalence of oxygen desaturation during ventilatory maneuvers at low level of PEEP in patients with moderate or severe ARDS

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Key information

Conditions

Acute Respiratory Distress Syndrome Lung Diseases Positive End Expiratory Pressure Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age : > 18 yo
  • inclusion criteria: ARDS, Mechanical ventilation, low PEEP maneuvers

Exclusion criteria

  • refusal to participate

Treatment and study plan

Primary outcomes

  1. prevalence of oxygen desaturation

    Time frame: 24 months

Study contacts

Contact information is provided by the study sponsor or research team.

Yoann Zerbib, MD

CONTACT

[email protected]

03 22 08 77 23

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Collaborators

  • Centre Hospitalier VALENCIENNES

Registry information

Acronym: DEBAS

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Jun 28, 2023
Registry last updated
Jul 10, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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