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Active, not recruiting

NCT Number: NCT05843487

Association Between Carotid Plaque Length and Cardiovascular Outcomes

This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No. 904 Hospital of the PLA Joint Logistics Support Force Wuxi). The study enrolled 5000 consecutive patients without known CAD who underwent first coronary angiography for stable chest pain and carotid ultrasound was performed during hospitalization from January 2017 through December 2018.

Active, not recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Carotid Plaque Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

No. 904 Hospital of the PLA Joint Logistics Support Force, Wuxi, Jiangsu, China

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About this study

Patients who had obstructive CAD (defined as ≥50% luminal stenosis) confirmed by coronary angiography and who underwent carotid scanning were included in the final analysis.Carotid ultrasonography was performed simultaneously, and carotid intima-media thickness (IMT), maximum thickness and length of all plaques were measured.The incidence of major adverse cardiovascular events was recorded during follow-up.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent coronary angiography for stable chest pain and carotid ultrasound simultaneously;
  • Patients with obstructive CAD (≥50% coronary stenosis);

Exclusion criteria

  • <18 years of age;
  • previous carotid surgery or significant carotid artery disease;
  • prior stroke or transient ischemic attack;
  • previously documented CAD (including history of myocardial infarction, acute coronary syndrome, or coronary revascularization);

Treatment and study plan

Primary outcomes

  1. major adverse cardiovascular events

    Time frame: 3 years

    cardiovascular death, myocardial infarction, ischemic stroke and coronary revascularization

Secondary outcomes

  1. all-cause death

    Time frame: 3 years

  2. cardiovascular death

    Time frame: 3 years

  3. myocardial infarction

    Time frame: 3 years

  4. ischemic stroke

    Time frame: 3 years

  5. coronary artery revascularization

    Time frame: 3 years

  6. heart failure

    Time frame: 3 years

Sponsors and collaborators

Lead sponsor

Changhai Hospital

Other

Collaborators

  • 904th Hospital of the Joint Logistics Support Force of the PLA
  • Gongli Hospital
  • Putuo Hospital, Shanghai University of Traditional Chinese Medicine
  • Yueyang Hospital, Shanghai University of Traditional Chinese medicine

Registry information

Important dates

Study start
2017
Primary completion
2022
Study completion
2030
First posted
May 6, 2023
Registry last updated
May 6, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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