Investigation of the Postprandial Response of Two Different PDO Cheeses on Metabolic Biomarkers

A pilot cross-over, randomized and single-blinded, intervention-clinical trial was conducted, in ten healthy men and women subjects, aged eighteen to thirty years, after random allocation into the control and the intervention group, received a high-fat and carbohydrates meal, containing Ladotyri Mytilinis (the authentic nonrefrigerated recipe) or Italian Parmesan, PDO cheeses. After a washout week, participants consumed the same meals, conversely. Differences on postprandial responses of serum total, High Density Lipoprotein (HDL-), Low Density Lipoprotein (LDL-) cholesterol, glucose, triglycerides and uric acid levels, as well as of plasma total antioxidant capacity according to Ferric Reducing Antioxidant Power method, were determined between groups in fasting, thirty minutes, one and a half hour, and three hours after meal intake.

Inclusion criteria

• Age 18-65 years
• Willingness to join and complete the nutritional intervention

Exclusion criteria

• Inability or unwillingness to provide informed consent
• Three-month nutritional supplement
• Age over 65 years or below 18 years
• Chronic diseases history
• Hemoglobin A1c - HbA1c > 5.7 %
• Abnormal Body Mass Index (BMI) (> 25 kg / m2)
• Abnormal hematological or biochemical profile (total cholesterol > 240 mg/dL, triglycerides > 250 mg/dL, glucose > 100 mg/dL)
• Alcohol overdose (> 40 g alcohol / day)
• Heavy smoking (> 10 cigarettes / day)
• Concurrent participation in another intervention study or unconsciousness in previous blood draws