Portal Hypertension Using Magnetic Resonance Elastography

This prospective study was conducted in a tertiary university hospital. The investigators researched the correlation between MRE-assessed stiffness of the liver and spleen and the Hepatic venous pressure gradient (HVPG) values. Furthermore, the investigator evaluated whether MRE-assessed stiffness reflected changes in portal hypertension (PH) after administering non-selective beta-blockers (NSBBs).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Portal Hypertension Digestive System Diseases Hypertension, Portal Liver Diseases Magnetic Resonance Imaging

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Wonju Severance Christian Hospital

Wŏnju, Gangwon-do, 22070, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

diagnosed liver cirrhosis
requiring prophylactic treatment of esophageal varices

Exclusion criteria

the coexistence of hepatocellular carcinoma
refractory ascites who regularly underwent large-volume paracentesis
the use of selective beta-blocker or carvedilol therapy for at least 4 weeks
undergoing liver transplantation
contraindication with magnetic resonance imaging

Treatment and study plan

MRE

Diagnostic Test

MRE was performed using a 3T system (Magnetom Skyra; Siemens, Erlangen, Germany) equipped with a combination of a 30-channel body and a 32-channel spine matrix coil.

Primary outcomes

Change of liver stiffness and spleen stiffness by MRE

Time frame: Change from baseline stiffness of MRE at 6 months
The change of portal pressure (HVPG) prior to and after treatment with NSBB

Time frame: Change from baseline and at 6 months

Interested in participating?

Completed

Looking for future studies?

Notify Me

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Official study title

Non-invasive Assessment of Portal Hypertension Using Quantitative Magnetic Resonance Imaging

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2023
First posted: Mar 1, 2023
Registry last updated: Mar 1, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed