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OpenTrials
Completed

NCT Number: NCT05662254

PERsonalized Mood Augmentation Trial for Depressed Mood

The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood.

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Key information

Conditions

Depression Behavior Behavioral Symptoms

Age range

15 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UC San Diego Health Psychiatry

San Diego, California, 92127, United States

About this study

The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood. After an initial period (2-4 weeks) of mood and lifestyle monitoring using smartphone and smartwatch data, participants will be assigned to an evidenced-based behavioral plan that target their lifestyle for 6 weeks. The trial will evaluate changes in depressed mood, associated health behaviors and cognition.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Mild to moderate depression per PHQ9 symptom ratings

Exclusion criteria

  • active substance abuse/dependence
  • psychotic disorders
  • bipolar disorder
  • eating disorder
  • displaying acutely suicidal behaviors

Treatment and study plan

Personalized Behavioral Intervention

Behavioral

Behavioral lifestyle intervention assigned according to each participant's mood and lifestyle data patterns.

Primary outcomes

  1. PHQ9

    Time frame: 12 weeks

    Depression Symptoms on the Patient Health Questionnaire 9-item (PHQ9) scale, min 0 max 27 with lower scores representing better outcome

Sponsors and collaborators

Lead sponsor

University of California, San Diego

Other

Registry information

Acronym: PERMA

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Dec 22, 2022
Registry last updated
Mar 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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