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NCT Number: NCT05437198

Study of Microbiological Diversity in Exhaled Air in COPD and Free of COPD

COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations.

a second collection for the year +1 will be made, at the same time (between October and March).

Recruiting

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Key information

Conditions

Chronic Obstructive Pulmonary Disease Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Intercommunal de Créteil

Créteil, 94010, France

Location status: Recruiting

About this study

The subjects will be recruited during a medical visit in the Departments of Pneumology and Occupational and Environmental Pathologies.

After information and inclusion of the subject in the study, a collection of clinical data, the state of health and the smoking status of the subject will be carried out by the clinical study technician.

A collection of the exhalation will also be carried out by the clinical study technician.

Several groups of subjects will be formed according to pathologies (COPD versus non-COPD), age and smoking status

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For COPD:

  • Patients with chronic obstructive pulmonary disease
  • Age: over 18

For non-COPD

  • Absence of chronic obstructive pulmonary disease
  • Age: between 18 and 30 years old and between 45 and 70 years old

Exclusion criteria

  • Taking certain medications in the month preceding the sample (antibiotics, systemic corticosteroids, immunosuppressants)
  • Person under guardianship or curatorship
  • Pregnant or breastfeeding women
  • Person unable to express his/her opposition, person deprived of liberty
  • Existence of a chronic infectious pulmonary pathology such as (dilation of the bronchi, cystic fibrosis)

Treatment and study plan

collection of human exhalation

Other

the collection of the exhalation will be carried out with a non-invasive device manufactured by a Chinese company.

The collection of exhalation consists of the subject inhaling through the nose and exhaling gently through the mouth through a plastic straw for a time set at 5 min in the device

Primary outcomes

  1. Number and dominant bacterial species in human exhalations of COPD subjects and non-COPD subjects

    Time frame: Baseline

    number and bacterial species

Secondary outcomes

  1. Number and dominant bacterial species in human exhalations according to smoking status

    Time frame: Baseline

    number and bacterial species

  2. Number and dominant bacterial species in human exhalations according to age

    Time frame: Baseline

    number and bacterial species

  3. Number and dominant bacterial species in human exhalations for patients returning for consultation 1 year apart during the winter season

    Time frame: 1 year

    number and bacterial species

Interested in participating?

Recruiting

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Centre Hospitalier Intercommunal Creteil

Other

Registry information

Official study title

Study of Microbiological Diversity in Exhaled Air in Adult Subjects With Chronic Obstructive Pulmonary Disease (COPD) and Subjects Free of COPD

Acronym: EXHALBIO

Important dates

Study start
2024
Primary completion
2028
Study completion
2029
First posted
Jun 29, 2022
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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