The Immune Response to Stroke

Some patients develop cognitive decline after a stroke, but we don't always understand the mechanisms. It has been proposed that a proportion of the patients develop an autoimmune immune response, and that this could potentially explain the cognitive decline in some of the patients. The current study aims to investigate this hypothesis in a subgroup of patients with stroke.

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Key information

Conditions

Stroke, Acute Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Akershus University Hospital

Lørenskog, Norway

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Stroke < 72 h
Age > 18 years

Exclusion criteria

Brain hemorrhage verified by CT or MRI scan
Previous or present immunological disease or other serious comorbidity
Ongoing immune respons after infection or vaccination < 1 month
Cognitive without ability to understand and/or give an informed consent to participate in the study

Treatment and study plan

Analysis of post-stroke immune responses

Other

Analysis of immune responses in peripheral blood

Primary outcomes

The B cell and T cell response in peripheral blood

Time frame: 1 day (subject inclusion)

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Sponsors and collaborators

Lead sponsor

University of Oslo

Other

Registry information

Important dates

Study start: 2021
Primary completion: 2025
Study completion: 2029
First posted: Mar 14, 2022
Registry last updated: Mar 14, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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