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Completed

NCT Number: NCT05220904

Perceptual Learning Improve Visual Function in Patients With Keratoconus

This project aims at non-progressive keratoconus patients with unsatisfactory visual acuity corrected by spectacles, and explores the effectiveness and maintenance of visual acuity improved by perceptual learning.

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Key information

Conditions

Keratoconus, Stable Corneal Diseases Eye Diseases Keratoconus

Age range

9 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zhongshan Ophthalmic Center, Sun Yat-sen University

Guangzhou, Guangdong, 510060, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 9 years or older;
  • Has been diagnosed as Keratoconus,BAD-D≥2.6;
  • Change of Kmax < 1.0 D and change of BAD-D <0.4175 betweem the last two Pentacam result;
  • The best corrected visual acuity of both eyes was between 0.1 and 1.0;
  • Has voluntarily agreed to participate in the study by signing the statement of informed consent.

Exclusion criteria

  • Has history of acute keratoconus;
  • Has other eye diseases or other diseases/conditions causing vision loss;
  • Has eye surgery history in the past 1year;
  • Is currently using local/systemic medications or other interventions that may affect visual function;
  • Receiving other treatments that may affect the results of this study, such as contact lenses during the study;
  • Has any known neurological diseases;
  • Participating in other studies currently that may affect the results of this study;
  • Study other reasons that the physician considers inappropriate for inclusion in the program.

Treatment and study plan

Spectacles

Device

Spectacle is the the most common treatment for refractive errors.

perceptual learning

Device

Blurred vision from the eyes can be improved by enhancing the brain's visual processing.

Primary outcomes

  1. 3-months corrected visual acuity

    Time frame: baseline；3 months.

    Mean changes of best corrected visual acuity between 3 months after perceptual learning training and baseline values.

Secondary outcomes

  1. corrected visual acuity of other time frame

    Time frame: 6,9,15 months

    Mean changes of best corrected visual acuity for 6,9,15 months.

  2. ucorrected visual acuity (UCVA)

    Time frame: 3,6,9,15 months

    Mean changes of ucorrected visual acuity (UCVA) for 3,6,9,15 months.

  3. contrast sensitivity function (CSF)

    Time frame: 3,6,9,15 months

    Mean changes of contrast sensitivity function (CSF) for 3,6,9,15 months.

Sponsors and collaborators

Lead sponsor

Zhongshan Ophthalmic Center, Sun Yat-sen University

Other

Registry information

Official study title

A Randomized Controlled Clinical Study of Perceptual Learning Improving Visual Function in Patients With Keratoconus

Acronym: KPL

Important dates

Study start
2022
Primary completion
2026
Study completion
2026
First posted
Feb 2, 2022
Registry last updated
Sep 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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