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Completed

NCT Number: NCT05087693

Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)

Salbutamol use is increased in areas with high levels of ozone pollution and the potential consequences of this are not well known. The purpose of this study is to examine the effect of salbutamol on lung function and inflammation in people with asthma and/or EIB exercising in ozone air pollution. To examine this, we are planning a randomized cross over trial where people with asthma and/or EIB complete sub maximal exercise in four conditions on four separate days. The four condition are: ozone + salbutamol, filtered air + salbutamol, ozone + placebo medication, and filtered air + placebo medication.

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Key information

Conditions

Asthma and/or Exercise Induced Bronchoconstriction Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Ozone Air Pollution Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Environmental Physiology Laboratory

Vancouver, British Columbia, V6T 1Z1, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Have asthma and/or EIB
  • Able to perform maximal exercise
  • Able to communicate sufficiently using the English language

Exclusion criteria

  • Allergic to salbutamol (also known as Ventolin)
  • Pregnant or potentially pregnant
  • Have a history of smoking
  • Had an upper respiratory tract infection within the last 4 weeks
  • Have a chronic respiratory disease other than asthma or EIB

Treatment and study plan

Salbutamol

Drug

Inhaling 200ug of salbutamol

Placebo medication

Drug

Inhaling placebo medication

Ozone

Other

Breathing 170ppb ozone

Filtered Air

Other

Breathing filtered air

Exercise

Other

Cycling at 60% of VO2max on a cycle ergometer

Primary outcomes

  1. Measured Before and 30 Minutes After Exercise in Each 1 Day Condition

    Time frame: Measured before and 30 minutes after exercise in each 1 day condition

    Measure of pulmonary function

  2. Change in FVC From Baseline to 30 Minutes After Exercise

    Time frame: Measured before and 30 minutes after exercise in each 1 day condition

    Measure of pulmonary function

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Registry information

Official study title

Examining the Effect of Salbutamol Use in Asthma and/or Exercise Induced Bronchoconstriction Whilst Exercising in Ozone Air Pollution

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Oct 21, 2021
Registry last updated
Mar 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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