Clinical Trial of HG146 Administered to Subjects With Advanced Solid Tumors or Lymphoma

Key Inclusion Criteria:

1 Subject must be >=18 years of age at the time of signing the informed consent.

2- Ia/Ib dose escalation phase（Part1 and Part 2A）：Subjects with advanced/Metastatic solid tumors or Lymphoma, who have progressed on, be intolerant of, or ineligible for, all available therapies for which clinical benefit has been established.

• Ib dose expansion phase（Part 2）:

• Cohort 1,Subjects with advanced/Metastatic solid tumors or Lymphoma, who have progressed on, be intolerant of, or ineligible for, all available therapies for which clinical benefit has been established, have not been treated with PD-(L)1 antibody； 2）Cohort 2,Subjects with advanced/Metastatic solid tumors or Lymphoma, who have progressed on, be intolerant of, or ineligible for, all available therapies for which clinical benefit has been established, have progressed on PD-(L)1 antibody； 3 Measurable disease per RECIST version 1.1 or Lugano 2014（If applicable）. 4 Has Eastern Cooperative Oncology Group (ECOG) Performance Status ≤1. 5 Has adequate organ function. 6 Signed informed consent form (ICF) and able to comply with study requirements.

Key Exclusion Criteria:

• Received prior therapies targeting HDAC.
• Symptomatic central nervous system (CNS) metastases that have required steroids within 4 weeks prior to first dose of study treatment.
• History of intolerant of anti-PD-(L)1 toxicity（Ib）.
• A condition requiring systemic treatment with either corticosteroids or other immunosuppressive medications within 14 days of enrollment.
• Major surgery or major injury <=28 days before the first dose of study treatment,or anticipated major surgery during the study.
• Received other anticaner therapies within 4 weeks prior to first dose of study treatment or 5 half life period of anticancer drug .
• Active infection requiring systemic treatment.
• Prior allogeneic bone marrow transplantation or other solid organ transplantation ( Ib)
• Active autoimmune disease or disease of impaired immune system(Ib).
• History of Adrenal insufficiency.(Ib)
• History orConcurrent condition of other malignant tumors.
• Recent (within the past 6 months) history of Unstable or serious diseases, such as pancreatitis, severe angina, prolonged QT interval, congestive heart failure, myocardial infarction, pulmonary hypertension, stroke, and severe seizures, etc.
• History of severe lung disease.
• Any illness or medical conditions that are unstable or could jeopardize the safety of the patient and his/her compliance in the study.