Self-Management Of Asthma By Forced Oscillation Technique

Inclusion criteria

• Age: 6-65 years old
• Diagnosis of persistent asthma
• Treatment level at study entry:

• For children 6-11 years: Step2 or Step3 of the GINA document
• For adolescents and adults 12-65 years: Step2 under daily low-dose inhaled corticosteroids (ICS), Step 3 or Step 4 of the GINA document
• Uncontrolled asthma (ACQ-5 > 1.5) that, according to the physician, does not warrant an immediate step-up of the treatment
• History of moderate or severe exacerbations in the twelve (12) months prior to baseline visit

Exclusion criteria

• Use of oral, rectal or parenteral glucocorticosteroids 30 days before enrolment
• Treatment with leukotriene receptor antagonist (LTRA)
• Treatment with maintenance and reliever therapy (SMART/MART)
• Smoking, current or previous with a history of 10 pack-years or more
• Documented COPD or other concomitant clinically important diseases or cognitive impairment that, according to the physician, may interfere with the subject's ability or safety to participate in the study
• Obesity (for subjects 6-19 years: BMI ≥ 95th percentile; for adults 20-65 years: BMI ≥ 40kg⋅m-2
• For school-age children (6-11 years old): gestational age at birth < 37 weeks or documented bronchopulmonary dysplasia (BPD)
• Prolonged absence from home during the monitoring period (i.e. at recruitment, expected ≥3 consecutive weeks for ≥2 times during the 9- month monitoring period) Subject currently enrolled in other clinical trials related or involving the study of the respiratory system
• History of near-fatal asthma
• Women who are pregnant, nursing or intending to become pregnant during the time of the study
• Absence of health insurance coverage (applies to French centres only)