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NCT Number: NCT04938804

Non-risk Based Lang Cancer Screening With a One-off LDCT

Guangzhou Lung-Care Project is a single-arm, prospective cohort study using one-time low-dose computed tomography for the early detection of LC, recruiting residents aged 40-74 years from four communities in Guangzhou between 2015 and 2021.The primary outcome was LC detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases, and to investigate the various factors associated with the development of LC.

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Key information

Conditions

Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

40 year–74 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510120, China

Location status: Recruiting

Location contact

Wenhua Liang, MD

CONTACT

[email protected]

+86-02-83062808

About this study

Guangzhou Lung-Care Project is a single-arm, prospective cohort study using one-time low-dose computed tomography for the early detection of LC, recruiting residents aged 40-74 years from four communities in Guangzhou between 2015 and 2021. Follow-up for post-screening management and survival was recorded. The primary outcome was LC detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases, and to investigate the various factors associated with the development of LC. Additionally, we compared the detection rates of LC and the proportion of stage I LC cases between "high-risk" and "non-high-risk" groups according to the National Comprehensive Cancer Network (NCCN) guidelines and Chinese guideline.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Minimum age of 40 years among the residents in Guangzhou

Exclusion criteria

  • Persons who had a diagnosis or treatment related to LC within the past 5 years, had undergone chest CT within the past year, or had significant cancer-related symptoms (e.g., hemoptysis, dyspnea, inability to climb two flights of stairs).

Treatment and study plan

Low-dose computed tomography

Device

The Low-dose computed tomography is conducted according to the guideline suggested by American College of Radiology.

Primary outcomes

  1. The detection rate of lung cancer

    Time frame: 11 years

    Lung cancer detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases.

  2. To investigate the various factors associated with the development of lung cancer

    Time frame: 11 years

    To investigate the various factors associated with the development of lung cancer

Secondary outcomes

  1. Detection rates of lung cancer and the proportion of stage I lung cancer cases between "high-risk" and "non-high-risk" groups

    Time frame: 11 years

    The detection rate of lung cancer among people with "high-risk" and "non-high-risk"factors

  2. Cost-effectiveness ratio (costs of examinations, diagnoses, and treatments)

    Time frame: 11 years

Study contacts

Contact information is provided by the study sponsor or research team.

Wenhua Liang, MD

CONTACT

[email protected]

+86-02-83062808

Sponsors and collaborators

Lead sponsor

The First Affiliated Hospital of Guangzhou Medical University

Other

Registry information

Official study title

Non-risk Based Lung Cancer Screening With One-time Low-dose Computed Tomography: a Prospective Cohort Study

Important dates

Study start
2015
Primary completion
2025
Study completion
2026
First posted
Jun 24, 2021
Registry last updated
Jan 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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