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NCT Number: NCT04838678

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

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Key information

Conditions

Hypertension Body Weight Cardiovascular Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

University of Texas Southwestern Medical Center

Dallas, Texas, 75231, United States

Location status: Recruiting

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Control - BMI<30, age 18-55
  • Hypertensive - BMI<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI>30, age 18-55 Obese-hypertensive- BMI>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring

Exclusion criteria

All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,

Treatment and study plan

Neuropeptide Y

Drug

intra-arterial infusion of neuropeptide Y

Primary outcomes

  1. Blood flow measured by doppler ultrasound

    Time frame: Acutely on the day of study

    brachial and femoral artery blood flow

  2. Muscle sympathetic nervous system activity

    Time frame: Acutely on the day of study

    recording of sympathetic nervous system activity from the peroneal or radial nerve

Interested in participating?

Recruiting

Interested in participating?

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Sponsors and collaborators

Lead sponsor

University of Texas Southwestern Medical Center

Other

Registry information

Official study title

Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension

Acronym: OB-HTN

Important dates

Study start
2021
Primary completion
2026
Study completion
2026
First posted
Apr 9, 2021
Registry last updated
Sep 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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