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NCT Number: NCT04829526

Firm Observational Clinical Unicenter Study on Guillain Barré Syndrome

The aim of this retrospective observational single-center cohort study is to gain a deeper understanding regarding the frequency, the clinical and electrophysiologic characteristics (e.g., the diagnostic work up), complications, treatment regimes, and their associations with specific courses of disease and outcomes in adult patients with the suspected or proven diagnosis of GBS.

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Key information

Conditions

Guillain-Barre Syndrome (GBS) Autoimmune Diseases Autoimmune Diseases of the Nervous System Chronic Disease Demyelinating Diseases Disease Attributes Guillain-Barre Syndrome Immune System Diseases Nervous System Diseases Neuromuscular Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Polyneuropathies Polyradiculoneuropathy Post-Infectious Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Clinic for Intensive Care Medicine; University Hospital Basel

Basel, 4031, Switzerland

Location status: Recruiting

About this study

Guillain Barré Syndrome (GBS) is a rare and life-threatening neurological emergency. The aim of this retrospective study including adult GBS patients from the last 15 years treated at the University Hospital of Basel is to assess data regarding diagnostic workup, treatment, clinical course including complications and outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • suspected diagnosis of GBS, who have been treated at the University Hospital of Basel from 01.01.2005-28.02.2021

Exclusion criteria

  • Patients with documented refusal of the general consent.

Treatment and study plan

Data Collection

Other

Retrospective extraction of demographic, clinical, laboratory, and electrophysiological data from the digital medical records

Primary outcomes

  1. frequency of GBS

    Time frame: one time retrospective assessment at baseline

    frequency of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  2. clinical characteristics of GBS

    Time frame: one time retrospective assessment at baseline

    clinical characteristics of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  3. electrophysiologic characteristics of GBS

    Time frame: one time retrospective assessment at baseline

    electrophysiologic characteristics of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  4. complications of GBS

    Time frame: one time retrospective assessment at baseline

    complications of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  5. treatment regimes of GBS

    Time frame: one time retrospective assessment at baseline

    treatment regimes of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

  6. outcomes of GBS

    Time frame: one time retrospective assessment at baseline

    treatment regimes of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel)

Interested in participating?

Recruiting

Interested in participating?

Request Info

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Official study title

Firm Observational Clinical Unicenter Study on Guillain Barré Syndrome (FOCUS on GBS)

Acronym: FOCUS on GBS

Important dates

Study start
2021
Primary completion
2026
Study completion
2026
First posted
Apr 2, 2021
Registry last updated
Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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