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NCT Number: NCT04433455

Influencing Factors of Cerebrovascular Disease and Cognition in Hemodialysis Patients

In this observational study, the investigators evaluate the influencing factors of cerebrovascular disease and cognition in hemodialysis patients.

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Key information

Conditions

Hemodialysis Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Cognition Disorders Cognitive Dysfunction Cognitive Impairment Mental Disorders Nervous System Diseases Neurocognitive Disorders Vascular Diseases

Age range

50 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Huashan Hospital

Shanghai, Shanghai Municipality, 200040, China

Location status: Recruiting

Location contact

Qian Zhang

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • maintenance hemodialysis patients who are younger than 85 years old and older than 50 years old, regardless of gender
  • dialysis vintage is greater than 3 months;

Exclusion criteria

  • Those with severe infection and anemia (Hb <60g / L);
  • Those with severe mental illness, metabolic diseases and immune system diseases;
  • Patients with abnormal liver function

Treatment and study plan

Primary outcomes

  1. cerebrovascular disease

    Time frame: 5 years

    Magnetic resonance images will be used to determine the severity of white matter hyperintensity, using the Scheltens scale. Score 2 or more is abnormal.

Secondary outcomes

  1. changes in cognitive function

    Time frame: 5 years

    The Mini-Mental State Examination (MMSE) will be used to assess the changes in cognitive function.The MMSE has a maximum score of 30 points. The scores are generally grouped as follows:

    25-30 points: normal cognition 21-24 points: mild dementia 10-20 points: moderate dementia 9 points or lower: severe dementiaThe Mini-Mental State Examination (MMSE) will be used to assess the changes in cognitive function.The MMSE has a maximum score of 30 points. The scores are generally grouped as follows: 25-30 points: normal cognition 21-24 points: mild dementia 10-20 points: moderate dementia 9 points or lower: severe dementia

Study contacts

Contact information is provided by the study sponsor or research team.

Jing Chen

CONTACT

[email protected]

862152889325

Sponsors and collaborators

Lead sponsor

Huashan Hospital

Other

Registry information

Official study title

Influencing Factors of Cerebrovascular Disease and Cognition in Hemodialysis Patients: an Observational Study

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
Jun 16, 2020
Registry last updated
Sep 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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