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Terminated

NCT Number: NCT04405024

Pilot Study on the Feasibility of Systematic Hepatitis C Screening of Hospitalized Patients

The Ministry of Health has set the target of eradicating hepatitis C (HCV) in France by 2025.

The goal is to validate the feasibility and value of conducting routine HCV screening in hospitalized patients.

Why the study stopped: The study was prematurely terminated due to major recruitment difficulties. Indeed, only one site was opened and participated in the study, with inclusions carried out in 2020.
Terminated

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHI Créteil, Créteil, France

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About this study

The number of undetected HCV-infected persons has been extrapolated to 75,000 according to the results of a 2014 study. Screening efforts have been set up in groups of people said to be at high viral risk: drug users, prisoners, precarious persons or migrants from highly endemic countries. Nevertheless, the concept of universal screening has not yet been adopted by the guardians and the Ministry.

It is in this context that "hepatitis free hospital" projects have been carried out in several French cities such as Nice, Nancy and Marseille.

The aim of the HOSPI-VHC study is to evaluate the feasibility and efficiency of systematic HCV screening in all medical and surgical departments of 4 National Association of Hepato-Gastroenterologists of General Hospitals (ANGH) hospitals. This pilot project is part of a public health screening program. It will evaluate the interest and usefulness of implementing universal screening in hospitalized patients without taking into account the existence of viral risk factors. This study will also make it possible to evaluate the implementation of a dedicated care pathway: number of patients screened, number of patients referred for consultation and number of patients accepting the consultation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient over 18 years of age
  • Hospitalized during the study period
  • Non-opposition for participation in the Protocol

Exclusion criteria

  • Patients under 18 years of age
  • Outpatient, long-stay, maternity and intensive care inpatients
  • Patients refusing blood collection
  • Patient may not understand the information sheet
  • Patient under guardianship

Treatment and study plan

Hepatitis C testing

Diagnostic Test

Hepatitis C Screening

Primary outcomes

  1. potential patient versus

    Time frame: 7 days

    Number of HCV serologies collected compared to the number of patients meeting the inclusion criteria during the study period.

Secondary outcomes

  1. HCV positive

    Time frame: 7 days

    Percentage positive for HCV

  2. Follow-up

    Time frame: 2 months

    Percentage of patients referred for consultation if HCV positive

  3. Polymerase chain reaction (PCR)

    Time frame: 7 days

    Percentage of HCV PCR positive patients

  4. Viral risk factor

    Time frame: 7 days

    Percentage of patients with a viral risk factor

  5. hepatic fibrosis

    Time frame: 7 days

    Percentage of patients with hepatic fibrosis

  6. treatment initiation

    Time frame: 2 months

    Percentage of patients benefiting from treatment initiation

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Sponsors and collaborators

Lead sponsor

Centre Hospitalier Intercommunal Creteil

Other

Collaborators

  • Association Nationale des Hépato-Gastroentérologues des Hôpitaux Généraux

Registry information

Official study title

Pilot Study of the Feasibility of Routine Inpatient Hepatitis C Screening

Acronym: HOSPI-VHC

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
May 28, 2020
Registry last updated
Sep 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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