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OpenTrials
Terminated

NCT Number: NCT04244032

Cognitive Enhancement Through Computerized Training

Alcohol use disorder is characterized by widespread neurocognitive impairments, however despite substantial advances in the intervention and treatment of alcohol use disorders, exceptionally few studies have been directed to improving these deficits. This project leverages computerized cognitive training, applied as an adjunct to inpatient treatment, to enhance neurocognitive recovery. This project informs public health and future intervention efforts by interrogating factors critical to intervention efficacy and clarifying relationships between neurocognitive recovery and treatment outcomes, including post-discharge alcohol consumption.

Why the study stopped: enrollment barriers
Terminated

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Key information

Conditions

Alcohol Use Disorder Alcohol-Related Disorders Alcoholism Chemically-Induced Disorders Mental Disorders Substance-Related Disorders

Age range

25 year–64 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Florida

Gainesville, Florida, 32610, United States

About this study

Programmatic investigation of neurocognitive functioning in alcohol use disorder (AUD) has revealed widespread and sustained impairments. Despite conceptual relevance to treatment efficacy, few AUD interventions have been directed to the remediation of these impairments. This project is responsive to this gap. It will answer critical questions regarding the potential of cognitive training (CT), applied as an adjunct to inpatient treatment, to improve cognitive recovery and post-discharge functional outcomes in AUD.

The current project will investigate the efficacy of two experimental cognitive training interventions in a sample of inpatients in treatment for AUD. While the effectiveness of CT to enhance function is supported by diverse literatures, it remains largely unexamined in AUD. The current project will interrogate the degree to which cognitive training interventions can "transfer" cognitive gains to untrained tasks/domains, and improve overall executive functioning. It will apply conceptual models from the CT and alcohol literatures to identify factors associated with CT efficacy. The impact of cognitive training on functional outcomes, including post-discharge drinking, will be investigated. Finally, relationships between cognitive recovery during treatment and post-discharge adaptation will be examined. Thus, the current work will be of substantial import to public health, alcohol science, and will inform future intervention efforts.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Minimum of 10 years of education
  • Meet DSM-5 criteria for alcohol use disorder

Exclusion criteria

  • Medical histories confounding interpretation regarding change in neuropsychological functioning (e.g., stroke)
  • Meet DSM-5 criteria for current/unremitted psychotic, panic, or bipolar disorders

Treatment and study plan

Working memory training

Behavioral

Participants complete up to 12 sessions of computerized training (30-45 min each) in a working memory task designed to utilize individually-adapted difficulty levels.

Inhibitory control training

Behavioral

Participants complete up to 12 sessions of computerized training (30-45 min each) in an inhibitory control task designed to utilize individually-adapted difficulty levels.

Bias Modification Training

Behavioral

Participants complete up to 12 sessions of computerized training (30-45 min each) in a bias modification task designed to utilize individually-adapted difficulty levels.

Primary outcomes

  1. Change in Working Memory Performance

    Time frame: Baseline to Post-Test, Up to 3 months

    Percent accuracy on neuropsychological measures indexing working memory capacity. Scores range from 0% to 100%, with higher percentages indicating better performance.

  2. Change in Inhibitory Control Performance

    Time frame: Baseline to Post-Test, Up to 3 months

    Response time, in seconds, on neuropsychological measures indexing inhibitory control capacity. Values represent the change in response time from baseline to follow-up.

  3. Change in General Executive Function Performance

    Time frame: Baseline to Post-Test, Up to 3 months

    Response time, in seconds, on neuropsychological measures indexing general executive functioning. Values represent the change in response time from baseline to follow-up.

Interested in participating?

Terminated

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Sponsors and collaborators

Lead sponsor

University of Florida

Other

Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Registry information

Important dates

Study start
2021
Primary completion
2023
Study completion
2024
First posted
Jan 28, 2020
Registry last updated
Sep 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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