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OpenTrials
Completed

NCT Number: NCT04172428

Comparison of Compact 3T, Conventional 3T, and 7T Scanners Using Task Based and Resting State fMRI

Comparison of 3 MRI scanners.

Completed

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Key information

Conditions

Healthy

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

About this study

Comparing the strengths and weaknesses of 3 different MRI scanners in their performance of a functional MRI (an MRI that shows which areas in the brain are active during some sort of task).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and Women aged 18-55

Exclusion criteria

  • Patients with safety contraindications to MRI scanning at 3T.
  • Patients unable to adequately perform the fMRI task due to physical, neurological, or cognitive disability.
  • Patients that demonstrate 3 mm or greater translational head motion during scanning of the fMRI rhyming task data sets.
  • Pregnant women.
  • Patients that have implanted medical devices or other safety contraindications for a 7T or 3T MRI exam.

Treatment and study plan

Functional MRI (fMRI)

Diagnostic Test

fMRI will be done on 3 separate MRI scanners to compare.

Primary outcomes

  1. Statistical maxima of fMRI language and motor area activations.

    Time frame: Approximately 6 months after last subject is scanned

    For the task-based fMRI comparison, a region of interest will be drawn around activation maps overlying Broca's and Wernicke's language areas as well as the hand motor area. The data regarding each of the three regions will be treated separately. The statistical maxima for functional activation within these areas will be measured and compared using the same areas and technique on the three scanner platforms to determine which is the highest. This will be performed using the PRISM software we already use clinically to interpret fMRI.

  2. Signal to noise ratio assessment of resting state.

    Time frame: Approximately 6 months after last subject is scanned

    For the resting state fMRI comparison, a standard measurement of signal to noise ratio will be employed specifically using the default mode network. This data will be reported separately from the task based outcome #1 as they are unrelated. Because this is a ratio is has no units of measurement.

Secondary outcomes

  1. Neuroradiologist preference for scanner array.

    Time frame: Approximately 6 months after last subject is scanned

    Two board certified neuroradiologists will simply rank the 3 different scanner platforms (3T, Compact 3T, or the 7T) from most to least preferred for interpreting language and motor task-based fMRI's. This will be their overall qualitative gestalt based on years of daily experience reading these types of studies.

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Nov 21, 2019
Registry last updated
Mar 17, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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