Predictive and Prognostic Value of Inflammatory Markers and microRNA in Stage IV Colorectal Cancer

Colorectal cancer (CRC) is responsible for 10% of the world-wide cancer incidence and mortality. Recent data have shown that tumors arising from different regions of the colon differ in their molecular characteristics which causes translate into a differential clinical outcome.Several studies described the role of microRNA expression in the initiation and progression of CRC and its response to different therapeutic strategies. Other studies have shown that systemic inflammation is a key determinant role of clinico-pathological outcomes in patients with CRC. We therefore aim to evaluate the expression of selected microRNA and inflammatory markers in patients with stage IV colorectal cancer and assess their correlation with tumor location, dietary patterns, survival rates, response to systemic chemotherapy and other clinic-pathological parameters. We believe that identifying a predictive and prognostic panel made up of circulating microRNA and inflammatory markers may perhaps explain the difference in outcome between right and left colon and perhaps impact the clinical practice in patients with stage IV colorectal cancer.

Inclusion criteria

• Newly diagnosed Stage IV colorectal cancer
• Treatment naïve
• For the control group: adult individuals (above 18 years) with no cancer disease

Exclusion criteria

Any disease or condition that may alter the inflammatory and immune status of subjects at baseline, such as:

• Diagnosis of inflammatory bowel disease such as ulcerative colitis and crohn's disease.
• Diagnosis of active systemic autoimmune disease
• Chronic / recent use of corticosteroids
• Use of immunosuppressant drugs