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Completed

NCT Number: NCT04105140

Oxytocin Effects on the Prosocial Learning

To investigate whether intranasal oxytocin (24 IU) treatment can influence prosocial learning behavior in males.

Completed

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Key information

Conditions

Healthy

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

School of Life Science and Technology, University of Electronic Science and Technology of China

Chengdu, Sichuan, China

About this study

In a double-blind, within-subject, placebo controlled design, investigators plan to investigate the effect of oxytocin treatment on prosocial learning. Before the self-administration, participants need to finish several questionnaires including IRI, AAS, BASBIS, SPSRQ, SES, PTM, STAI, BDI, ASQ and PNAS. They would finish the PANAS again before the scanning.

Participants are informed that they perform the reward learning task either for themselves, another (unknown) person or no one (control). In the probabilistc reward learning task, associations with two stimuli with different reward probabilities are learned via monetary feedback (reward ￥1 or no reward ￥0). After the experiment, participants need to finish the PANAS.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • without past or current psychiatric or neurological disorders

Exclusion criteria

  • history of head injury
  • medical or psychiatric illness

Treatment and study plan

Oxytocin

Drug

intranasal administration of oxytocin (24 IU)

Placebo

Drug

intranasal administration of placebo (24 IU)

Primary outcomes

  1. Neural processing during feedback based on prosocial learning assessed by fMRI scanner

    Time frame: 1 hour

    fMRI BOLD indices of neural processing learning related brain regions will be compared between the treatment administrations.

Secondary outcomes

  1. Behavioral learning performance measured by E-prime

    Time frame: 1 hour

    Learning performance will be compared between the treatment administrations by calculating the accuracy of learning.

Sponsors and collaborators

Lead sponsor

University of Electronic Science and Technology of China

Other

Registry information

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Sep 26, 2019
Registry last updated
Sep 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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