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NCT Number: NCT04103281

Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis

In this research study we want to learn more about the characteristics of neutrophils that are present in the blood and secretions from a breathing tube of patients with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell that are part of the body's immune system. Even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in the lungs in patients with sepsis. Neutrophils can change their character in sepsis. Because of this, it is important for doctors to know what kind of neutrophils are in the blood and secretions from the breathing tube of patients with sepsis so that they can work to develop therapies to prevent these cells from being harmful.

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Key information

Conditions

Sepsis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

2 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Boston Children's Hospital

Boston, Massachusetts, 02115, United States

Location status: Recruiting

Location contact

Koichi Yuki, MD

CONTACT

[email protected]

617-355-6225

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Case Inclusion Criteria:

  • sepsis patient in the ICU with a breathing tube

Control Inclusion Criteria:

  • scheduled for an elective surgical procedure and need preoperative blood draw or will have an intravenous catheter placed for the purpose of their surgical procedure
  • Plan to have endotracheal tube for planned procedures.

Exclusion criteria

  • On chronic immunosuppressive drugs such as chronic corticosteroid use, or preexisting immunodeficiency diseases (oncology patients, patients with transplantation)

Treatment and study plan

sepsis

Other

Sepsis patients in the ICU with a breathing tube

Primary outcomes

  1. Neutrophil characteristics

    Time frame: One day

    measure and report β2 integrin expression on neutrophils from blood and tracheal aspirate between sepsis patients and non-sepsis patients in pediatric population

Study contacts

Contact information is provided by the study sponsor or research team.

Koichi Yuki, MD

CONTACT

[email protected]

617-355-6225

Sponsors and collaborators

Lead sponsor

Boston Children's Hospital

Other

Registry information

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
Sep 25, 2019
Registry last updated
Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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