Leiden University Medical Center
Leiden, Netherlands
NCT Number: NCT04076709
Many surgical procedures are performed using the laparoscopic approach. However, insufflation of the abdomen (pneumoperitoneum) has detrimental hemodynamic effects. The investigators intend to investigate the effect of deep neuromuscular block and nociception guided anaesthesia on hemodynamic variables during pneumoperitoneum for lower abdominal laparoscopic surgery.
Looking for future studies?
Notify Me18 year and older
All sexes
Interventional
Not applicable
Leiden, Netherlands
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
ASA 1-3;
Exclusion criteria
Deep neuromuscular blockade (PTC 1-2) Nociception level index (NOL) target 10-25
Time frame: 30 minutes after installation of pneumoperitoneum
Mean arterial pressure
Time frame: 5 minutes after installation of pneumoperitoneum
Mean arterial pressure
Time frame: 60 minutes after installation of pneumoperitoneum
Mean arterial pressure
Time frame: 5 minutes after installation of pneumoperitoneum
Cardiac output (l/min) as measured by non invasive arterial pulse contour anlysis
Time frame: 30 minutes after installation of pneumoperitoneum
Cardiac output (l/min) as measured by non invasive arterial pulse contour anlysis
Time frame: 60 minutes after installation of pneumoperitoneum
Cardiac output (l/min) as measured by non invasive arterial pulse contour anlysis
Time frame: 5 minutes after installation of pneumoperitoneum
Left ventricular ejection fraction measured by TEE
Time frame: 30 minutes after installation of pneumoperitoneum
Left ventricular ejection fraction measured by TEE
Time frame: 60 minutes after installation of pneumoperitoneum
Left ventricular ejection fraction measured by TEE
Looking for future studies?
Notify MeLeiden University Medical Center
Other
The Impact of Neuromuscular Relaxation and Nociception Guided Anaesthesia on Hemodynamic Variables During Lower Abdominal Laparoscopic Surgery: a Strategy Trial.
Acronym: RELAX-LAP
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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