Ultrafine Particles and Fetal Contamination

The objective of this study is to evaluate the transplacental passage of fine and ultrafine particles (nanoparticles) inhaled by the mother.

Completed

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Key information

Conditions

Lung; Premature Female Urogenital Diseases and Pregnancy Complications Obstetric Labor Complications Obstetric Labor, Premature Pollution; Exposure Pregnancy Complications Premature Birth Urogenital Diseases

Sex eligibility

Female

Study type

Observational

About this study

Epidemiological studies have demonstrated the harmful effects of particulate air pollution on the progress of pregnancy and postnatal health.

Experimental studies have suggested the transplacental passage of asbestos fibers, but despite the strong growth in the use and production of fine and ultrafine particles, no study has examined the permeability of the placenta to these compounds or the exposures fetuses that may result.

The objective of this study is to evaluate the transplacental passage of fine and ultrafine particles (nanoparticles) inhaled by the mother.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All women volunteers for whom a medical termination of pregnancy is proposed for a fetus older than 22 weeks (weight over 500g).

Exclusion criteria

Refusal of participation of the patient.
Fetus with malformation syndrome affecting pulmonary perfusion.

Treatment and study plan

Pulmonary Tissue Collection

Procedure

Pulmonary Tissue Collection

Primary outcomes

Presence of fine particles in fetal lung samples yes/no

Time frame: At the screening

Analysis in electron microscopy

Sponsors and collaborators

Lead sponsor

University Hospital, Bordeaux

Other

Registry information

Official study title

Study of the Permeability of Atmospheric Particles Placenta (Fine and Ultrafine Particles): Analysis of Fetal Retention

Acronym: FOETOPUF

Important dates

Study start: 2009
Primary completion: 2012
Study completion: 2012
First posted: Aug 28, 2019
Registry last updated: Jun 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed