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OpenTrials
Completed

NCT Number: NCT04033965

Corellation of Mutations, TILs and Age in Breast Cancer

Age may pertain to different tumor genotype characteristics which may interfere with treatment efficacy and prognosis. The investigators investigated the distribution and prognostic effect of mutations (mut) and tumor infiltrating lymphocyte (TILs) in young and elderly early breast cancer patients (pts).

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Key information

Conditions

Breast Cancer Breast Diseases Breast Neoplasms Neoplasms Neoplasms by Site Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women with early breast cancer <35 years old or >65 years old

Exclusion criteria

  • NA

Treatment and study plan

Corellation of Mutations, TILs and Age in Breast Cancer

Genetic

Primary outcomes

  1. Assessment of the prevalence of gene mutations in women <=35 years old with early breast cancer.

    Time frame: Up to 13 years

  2. Assessment of the prevalence of gene mutations in women >65years old with early breast cancer.

    Time frame: Up to 13 years

  3. Evaluation of Tumor Infiltrating Lymphocytes (TILs) density using descriptive statistics in women <=35 years old with early breast cancer.

    Time frame: Up to 13 years

  4. Evaluation of Tumor Infiltrating Lymphocytes (TILs) density using descriptive statistics in women >65 years old with early breast cancer.

    Time frame: Up to 13 years

  5. Evaluation of the prognostic effect of gene mutations and Tumor Infiltrating Lymphocytes with respect to Overall Survival in women <=35 years old with early breast cancer

    Time frame: Up to 13 years

  6. Evaluation of the prognostic effect of gene mutations and Tumor Infiltrating Lymphocytes with respect to Overall Survival in women >65 years old with early breast cancer.

    Time frame: Up to 13 years

Sponsors and collaborators

Lead sponsor

Hellenic Cooperative Oncology Group

Other

Registry information

Official study title

Tumor Mutational Patterns and Infiltrating Lymphocyte Density in Young and Old Patients With Breast Cancer

Important dates

Study start
1997
Primary completion
2010
Study completion
2010
First posted
Jul 26, 2019
Registry last updated
Jul 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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