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OpenTrials
Completed

NCT Number: NCT03579381

Specimen Repository for HIV Immunopathogenesis

Specimen Repository for HIV Immunopathogenesis Studies

Completed

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Key information

Conditions

HIV-1-infection Acute HIV Infection

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

AIDS Healthcare Foundation - Public Health Division

Los Angeles, California, 90027, United States

About this study

The goal is to build a large specimen repository for collaborating scientists to run studies of immunity and HIV-1.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • HIV positive (acutely infected, viremic and elite controllers)
  • Signed Informed Consent Form
  • Age at least 18 years old
  • Immune controllers, two types: "Elite suppressors" (HIV-positive with any three consecutive plasma HIV-1 RNA PCR undetectable while off treatment) or "viremic suppressors" (HIV-positive with any three consecutive HIV-1 RNA PCR <3000 while off treatment).
  • Acutely infected subjects:

Persons identified to have a negative HIV antibody response (ELISA) but positive detection of HIV-1 in the blood (RT-PCR) or individuals who have evidence of a recent (past 30 days) HIV negative result along with a current HIV positive result.

Exclusion criteria

  • Uncontrolled bleeding diathesis.
  • Pregnant.
  • Inability to provide informed consent.

Treatment and study plan

Primary outcomes

  1. HIV progression from acute infection to viral suppression

    Time frame: 2 years

    Outcomes will depend on scientists who use the samples for further study

  2. HIV progression and control by elite and viremic suppressors

    Time frame: 2 years

    Outcomes will depend on scientists who use the samples for study

Sponsors and collaborators

Lead sponsor

AIDS Healthcare Foundation

Other

Collaborators

  • University of California, Los Angeles

Registry information

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Jul 6, 2018
Registry last updated
Jan 12, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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