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OpenTrials
Completed

NCT Number: NCT03401944

Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.

The study investigates effects related to muscle protein metabolism at provision of Total Parenteral nutrition.

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Key information

Conditions

Wasting;Muscle(S) Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Surgery

Gothenburg, SE 41345, Sweden

About this study

Randomized study investigating alterations in muscle protein metabolism at provision of parenteral nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Major gastrointestinal surgery
  • Assumed need of post-operative artificial nutrition.

Exclusion criteria

  • Insulin dependent diabetes
  • Steroid medication

Treatment and study plan

TPN

Drug

Other names: TPN infusion

Control

Other

Other names: Physiological saline infusion

Primary outcomes

  1. Muscle protein metabolism

    Time frame: Single evaluation point at 12-14 hours following the start of overnight infusion.

    Alterations in muscle protein metabolism will be assessed by various standard techniques for gene and protein expression. Combined measurements of cell-signaling molecules representing anabolic and catabolic signaling pathways will be evaluated in relation to transcription of muscle myosin proteins.

Sponsors and collaborators

Lead sponsor

Göteborg University

Other

Registry information

Important dates

Study start
2005
Primary completion
2014
Study completion
2014
First posted
Jan 17, 2018
Registry last updated
Jan 23, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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