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NCT Number: NCT03351595

Ewha Birth and Growth Study (Birth Cohort)

The Ewha Birth and Growth Study is a prospective birth cohort established at Ewha Womans University Mokdong Hospital in Seoul, Republic of Korea. Pregnant women were recruited between 2001 and 2006, and their offspring were followed longitudinally from birth through childhood, adolescence, and young adulthood.

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Key information

Conditions

Pediatric Health Cardiometabolic Health Growth & Development

Sex eligibility

All sexes

Study type

Observational

Primary location

Ewha Womans University Seoul Hospital

Seoul, South Korea

About this study

The cohort was composed of mothers who received prenatal care between 24 and 28 weeks of gestation and were recruited between 2001 and 2006. After delivery, information on birth outcomes was collected, and mail surveys were conducted when the offspring were 6, 12, 18, and 24 months of age.

Regular follow-up examinations were conducted at 3 and 5 years of age, annually from 7 through 12 years of age, and once during adolescence at 13 to 15 years of age. Follow-up examinations continued into young adulthood, with an examination at 19 years of age.

During follow-up examinations, after an 8-hour overnight fast, blood samples (3 mL EDTA blood and 5 mL serum) were obtained from participants by venipuncture, and urine samples were collected. Assessments included physical growth, blood pressure, metabolic biomarkers, dietary intake, psychological and behavioral measures, socioeconomic status, physical activity, and other health-related factors.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pregnant women who received prenatal care between 24 and 28 weeks of gestation and were enrolled between 2001 and 2006.
  • Individuals who could participate in scheduled follow-up examinations and comply with the study requirements.

Exclusion criteria

  • Individuals considered unable to participate in the study procedures for other reasons, based on the investigator's judgement.

Treatment and study plan

Primary outcomes

  1. Physical growth assessed by anthropometric measurements

    Time frame: At 3 and 5 years of age; annually from 7 through 12 years of age; at 13 to 15 years of age; and at 19 years of age

    Anthropometric measurements were obtained during scheduled follow-up examinations to assess longitudinal physical growth. Participants received individualized health examination results following the assessments.

Secondary outcomes

  1. Blood pressure assessed during follow-up examinations

    Time frame: At 3 and 5 years of age; annually from 7 through 12 years of age; at 13 to 15 years of age; and at 19 years of age

    Systolic and diastolic blood pressure were measured during scheduled follow-up examinations.

  2. Metabolic biomarkers assessed during follow-up examinations

    Time frame: At 3 and 5 years of age; annually from 7 through 12 years of age; at 13 to 15 years of age; and at 19 years of age

    Fasting blood samples were collected during scheduled follow-up examinations to assess metabolic biomarkers, including total cholesterol, HDL cholesterol, triglycerides, glucose, uric acid, and other metabolic biomarkers.

Sponsors and collaborators

Lead sponsor

Ewha Womans University

Other

Collaborators

  • National Research Foundation of Korea

Registry information

Official study title

Evaluation of Influencing Factors Affecting Childhood Metabolic Indicators in Korea (Repeated Measures Analysis; Longitudinal Birth Study)

Important dates

Study start
2001
Primary completion
2026
Study completion
2026
First posted
Nov 24, 2017
Registry last updated
Sep 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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