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NCT Number: NCT02917707

Integrative Analysis of CRC Liver Metastasis

The investigators will perform integrative analysis of CRC liver metastasis

Recruiting

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Key information

Conditions

Metastasis Neoplasm Metastasis Neoplasms Neoplastic Processes Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ganzhou City People's Hospital, Ganzhou, Jiangxi, China

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About this study

The investigators will analyzed proteomes of paired normal colorectal tissues and colorectal cancer (CRC) with or without liver metastasis, sequenced transcriptomes, performed whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal colorectal tissue, primary colorectal carcinoma, and its synchronous matched liver metastasis, as well as analyzed genomics of CRC characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≤ 75 years with histologically proven CRC
  • No severe major organ dysfunction
  • WHO performance status of 0 or 1
  • No prior cancer chemotherapy

Exclusion criteria

  • Age ≥ 76
  • Severe major organ dysfunction
  • World Health Organization (WHO) performance status of >1
  • Prior cancer chemotherapy

Treatment and study plan

normal colorectal tissues

Other

The investigators will extract total protein, DNA and RNA from these groups.

Other names: primary colorectal carcinoma tissues, liver metastasis tissues

Primary outcomes

  1. 5 years overall survival

    Time frame: 5 years

Secondary outcomes

  1. 5 years disease-free survival

    Time frame: 5 years

Interested in participating?

Recruiting

Interested in participating?

Request Info

Sponsors and collaborators

Lead sponsor

Da Fu

Other

Collaborators

  • Ganzhou City People's Hospital

Registry information

Acronym: CRC-LM

Important dates

Study start
2016
Primary completion
2026
Study completion
2026
First posted
Sep 28, 2016
Registry last updated
Sep 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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