Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus

60 individuals were subdivided into 2 groups, 30 patients with oral lichen planus, 30 control individuals. Expression of miRNA-138 and cyclin D1 were evaluated in oral mucosa utilizing Quantitative real-time polymerase chain reaction and immunohistochemistry.

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Key information

Conditions

Oral Lichen Planus Lichen Planus Lichen Planus, Oral Lichenoid Eruptions Mouth Diseases Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases Stomatognathic Diseases

Age range

45 year–65 year

Sex eligibility

All sexes

Study type

Observational

About this study

60 individuals were subdivided into 3 groups, into 2 groups, 30 patients with oral lichen planus, 30 control individuals having age, gender and periodontal status matched with both patients groups acting as a control group. Relative gene expression of miRNA-138 was estimated using Quantitative real-time polymerase chain reaction technique in oral mucosa of both oral lichen planus patients and control subjects. Sub grouping of oral lichen planus patients were performed into reticular, atrophic and erosive groups (n=10 each). Cyclin D1 gene expression was estimated using Quantitative real-time polymerase chain reaction technique and Cyclin D1 protein level was estimated using immunohistochemistry.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with oral lichen planus.

Exclusion criteria

any systemic disease other than oral lichen planus.
smokers.
pregnant females.
periodontal diseases.

Treatment and study plan

Primary outcomes

expression of miRNA-138

Time frame: 1 day

expression of miRNA-138 in oral mucosa of patients with oral lichen planus

Secondary outcomes

gene expression of cyclin D1

Time frame: 1 day

gene expression of cyclin D1 in oral mucosa of patients with oral lichen planus
protein expression of cyclin D1

Time frame: 1 day

protein expression of cyclin D1 in oral mucosa of patients with oral lichen planus

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Expression of miRNA-138 and Cyclin D1 in Oral Lichen Planus (A Study Utilizing Immunohistochemistry and Real-time Polymerase Chain Reaction)

Important dates

Study start: 2015
Primary completion: 2015
Study completion: 2016
First posted: Jul 15, 2016
Registry last updated: Jul 15, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed