Natural History, Pathogenesis, and Outcome of Ocular Disorders

The National Eye Institute (NEI) is conducting a study to evaluate and provide standard treatment to participants with various diagnosed and undiagnosed ocular conditions.

Objective: The primary objective of this protocol is to collect data and specimens generated

through clinical care procedures. Through this primary objective, the secondary objectives (establish a resource of patients with ocular conditions to facilitate recruitment into new research protocols at the NEI, gain additional knowledge about the course of specific ocular diseases and characterize the natural history of such diseases (to generate hypotheses for future clinical research studies), and evaluate the effects of standard of care treatments) may be achieved.

• INCLUSION CRITERIA:

To be eligible, the following inclusion criteria must be met, where applicable.

• Have a diagnosed, undiagnosed or suspected eye disease.
• Have the ability to understand and sign an informed consent or have a parent/legal guardian do so if they are minor children or a legally authorized representative (LAR) to provide consent for adults without consent capacity.

Exclusion criteria

A participant is not eligible if any of the following exclusion criteria are present.

• Are unwilling to give informed consent or assent when applicable.
• Are unwilling or unable to be followed as clinically indicated.
• Have a systemic disease that compromises the ability of NEI clinicians to provide adequate ophthalmologic examination or treatment.