Exploratory Study Using Positron Emission Tomography With TS-121 and [11C]TASP0410699 in Healthy Adult Male Subjects

Inclusion criteria

• Healthy males 18 - 55 years of age (at time of initial informed consent)
• Body weight ≥ 50 kg
• Body Mass Index (BMI) 18 - 30 kg/m2
• Male subjects with partners of childbearing potential must agree to use appropriate and effective measures of contraception for 90 days following drug administration

Exclusion criteria

• Prescription, over-the-counter or herbal medications, supplements, within 14 days before the study.
• Clinically significant abnormal electrocardiogram, physical examination, or hematology, biochemistry, hormone, or urinalysis values at screening & baseline.
• Significant history &/or presence of hepatic, renal, cardiovascular, hemodynamic, pulmonary, gastrointestinal, hematological, CNS, immunologic, ophthalmologic, metabolic, endocrine, or oncological disease or condition within last 5 years.
• Current use of tobacco or tobacco-containing products, recent history of alcohol or drug abuse OR positive urine screen for alcohol or controlled substances at screening or baseline.
• History &/or current evidence of serologic positive results for hepatitis B or C, or HIV.
• Donation or acute loss of 450 milliliters or more of blood or plasma, within 60 days of the study.
• Any subject who has received treatment with a non-FDA approved drug within 30 days of study screening.
• Subjects who suffer from claustrophobia.
• Current, past, or anticipated exposure to radiation in the workplace or participation in other research studies involving ionizing radiation that would exceed the yearly dose limits for normal subjects.