Adaptive Optics Retinal Imaging

Objective: The objective of this protocol is to collect and assess adaptive optics (AO) retinal images of normal and diseased eyes.

Study Population: Three hundred and fifty (350) participants with eye diseases and 250 normal volunteers will be enrolled.

Design: This is an observational protocol which will enroll 350 participants with various eye diseases and 250 age-matched healthy volunteers over five years. In general, participants will undergo a complete ophthalmic examination including assessments of visual acuity, intraocular pressure, and a dilated ocular examination. Imaging will be performed using adaptive optics instruments deployed in the NEI Eye Clinic.

Outcome Measures: The primary outcome for this protocol is qualitative and quantitative assessment of the AO images with comparisons of normal and diseased states.

• INCLUSION CRITERIA:

Participants will be eligible if they:

• Are 12 years of age or older.
• Have the ability to cooperate with an eye exam and adaptive optics imaging.
• Have the ability to understand and sign an informed consent or have a parent/legal guardian to do so if they are minor children.
• Have an eye disease or are a healthy volunteer with a normal eye exam (no visually-significant eye findings on examination).

Exclusion criteria

Participants will not be eligible if:

-They have a condition which prevents adequate images from being obtained (e.g. unstable fixation or media opacity).

Exclusion criteria

FOR FLUORESCEIN AND/OR INDOCYANINE GREEN IMAGING

Partaicipants are not eligible for fluorescein and/or indocyanine green imaging if they:

• Are under 18 years of age.
• For participants who will undergo fluorescein imaging have a history of adverse reaction to fluorescein.
• For participants who will undergo indocyanine green imaging have a history of adverse reaction to indocyanine green dye, know or suspected allergies to iodine or shellfish.