University College London
London, United Kingdom
NCT Number: NCT02298530
Assess the effects of adding theanine to a caffeinated beverage on changes in blood pressure during acute mental stress.
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Notify Me18 year–45 year
All sexes
Interventional
Not applicable
London, United Kingdom
Caffeine and (mental) stress can increase blood pressure. In a typical everyday and/or work environment they commonly coincide. Tea has the reputation of being a relaxing drink. L-theanine is an amino acid found almost exclusively in tea. In a previous study it was shown that caffeine increased blood pressure, while theanine antagonised these effects. In the current study the effect of theanine to a placebo on blood pressure are directly compared.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Beverage containing caffeine and theanine
Beverage containing caffeine
Time frame: Between 30-45 minutes after test product intake
Systolic blood pressure during acute mental stress
Time frame: Between 30-45 minutes after test product intake
Diastolic blood pressure during acute mental stress
Time frame: Between 45-60 minutes after test product intake
Systolic blood pressure immediately after acute mental stress
Time frame: Between 45-60 minutes after test product intake
Diastolic blood pressure immediately after acute mental stress
Time frame: -15 and 45 relative to test product intake
Self-reported mental state: State-Trait Anxiety Inventory
Time frame: -10, 45 minutes relative to test product intake
Self-reported mental state: University Of Wales Institute of Science and Technology mood adjective questionnaire
Time frame: -5, 45 min relative to test product intake
Concentration of cortisol in saliva
Time frame: Between 30-45 minutes after test product intake
Heart rate during acute mental stress
Time frame: Between 45-60 minutes after test product intake
Heart rate immediately after acute mental stress
Time frame: Between 30-45 minutes after test product intake
Heart rate variability during acute mental stress
Time frame: Between 45-60 minutes after test product intake
Heart rate variability immediately after acute mental stress
Time frame: Between 30-45 minutes after test product intake
Task performance on STROOP task
Time frame: Between 30-45 minutes after test product intake
Task performance on mirror tracing task
Time frame: Between 80-270 minutes after test product intake
Ambulatory systolic blood pressure during free living phase
Time frame: Between 80-270 minutes after test product intake
Ambulatory diastolic blood pressure during free living phase
Time frame: 140, 200 and 260 minutes after test product intake
Concentration of cortisol in saliva during free living phase
Time frame: 140, 200 and 260 minutes after test product intake
Self-reported mental state: State-Trait Anxiety Inventory during free living phase
Time frame: 140, 200 and 260 minutes after test product intake
Self-reported mental state: University Of Wales Institute of Science and Technology) mood adjective questionnaire during free living phase
Time frame: Between 30-45 minutes after test product intake
Mean pulse pressure during mental stress
Time frame: Between 45-60 minutes after test product intake
Mean pulse pressure after acute mental stress
Time frame: 7 consecutive days prior to the lab sessions
Mental well being as assessed by on line survey an each evening during the 7 day period the accelerometer is worn.
Time frame: 7 consecutive days prior to the lab sessions
Habitual patterns in physical activity as measured by accelerometer
Time frame: Screening
State-Trait Anxiety Inventory (STAI) - Trait version, covariate
Time frame: Screening
Center for Epidemiologic Studies Depression scale, covariate
Time frame: Screening
CISS coping scale, covariate
Time frame: Screening
UCLA loneliness scale, covariate
Time frame: Screening
Perceived Stress Scale, covariate
Unilever R&D
Industry
A Study to Determine the Acute Effects of a Tea Component on Blood Pressure and Mental Stress Challenge
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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