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NCT Number: NCT02160483

Functional Brain Imaging and Psychological Testing in Women With Chronic Pelvic Pain

Functional magnetic resonance imaging in women with chronic pelvic pain using arterial spin labelling, functional connectivity, diffusion tensor imaging and magnetic resonance spectroscopy.

Why the study stopped: This study is not feasible to conduct as functional brain imaging capability is inadequate. CIRB acknowledged in June 2016.
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Key information

Conditions

Pelvis Pain Chronic Adenomyosis Endometriosis Endometriosis of Uterus Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Urogenital Diseases Uterine Diseases

Age range

21 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

KK Women's and Children's Hospital

Singapore, 229899

About this study

Multimodal magnetic resonance neuroimaging will be utilised. Arterial spin labelling is tightly coupled with cerebral metabolism and can be used as a marker of neural activity. Resting state magnetic resonance imaging which measures synchronous activity across the brain, allows detection of functional connectivity of intrinsic brain network. Diffusion tensor imaging detects the anisotropic water diffusion in axonal fibres can provide information on connectivity and fibre tracts. Magnetic resonance spectroscopy would enable the levels of neurotransmitter to be elucidated.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chronic pelvic pain
  • Endometriosis

Exclusion criteria

  • Contraindication to magnetic resonance imaging

Treatment and study plan

functional magnetic resonance imaging

Other

3 Tesla magnetic resonance imaging

Other names: FMRI

Primary outcomes

  1. Number of participants with increase in insula anterior cingulate cortex signal on magnetic resonance imaging

    Time frame: 1 hour

    Magnetic resonance imaging using arterial spin labelling, functional connectivity, diffusion tensor imaging, magnetic resonance imaging

Secondary outcomes

  1. Number of subjects in psychological testing with increased anxiety, depression and pain catastrophizing scores

    Time frame: 1 hour

    Anxiety, depression and pain catastrophizing scales used for psychological testing

Sponsors and collaborators

Lead sponsor

KK Women's and Children's Hospital

Other Gov

Collaborators

  • Duke-NUS Graduate Medical School

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Jun 10, 2014
Registry last updated
Aug 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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