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Completed

NCT Number: NCT02142855

Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training

The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. Secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. This project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.

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Key information

Conditions

Healthy

Age range

18 year–75 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Nottingham

Derby, Derbyshire, DE22 3DT, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy male volunteers
  • Body mass index 18-30 kg/m2
  • Aged 18-35 and 65-75 years

Exclusion criteria

  • Participation in a formal exercise regime,
  • A BMI < 18 or > 30 kg/m2,
  • Active cardiovascular disease,
  • Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs,
  • Cerebrovascular disease,
  • Respiratory disease,
  • Metabolic disease,
  • Active inflammatory bowel or renal disease,
  • Malignancy,
  • Recent steroid treatment (within 6 months) or hormone replacement therapy,
  • Clotting dysfunction,
  • Musculoskeletal or neurological disorders,
  • Family history of early (<55y) death from cardiovascular disease

Treatment and study plan

Concentric Exercise Training

Behavioral

8 weeks concentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Eccentric Exercise Training

Behavioral

8 weeks eccentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Primary outcomes

  1. Muscle protein synthesis

    Time frame: 0 - 8 weeks

    Comparison of muscle protein synthesis using D2O in young and older individuals and in response to 8 weeks concentric or eccentric exercise training

Secondary outcomes

  1. Tendon protein synthesis

    Time frame: 0 - 8 weeks

    Comparison of tendon protein synthesis in young and older individuals and in response to 8 weeks concentric or eccentric exercise training

Other outcomes

  1. Muscle function

    Time frame: 0 - 8 weeks

    Muscle strength, force and power in young and older individuals and in response to 8 weeks concentric or eccentric exercise training

Sponsors and collaborators

Lead sponsor

University of Nottingham

Other

Collaborators

  • Biotechnology and Biological Sciences Research Council

Registry information

Official study title

Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training: a Novel Temporospatial Approach

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
May 20, 2014
Registry last updated
Oct 30, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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