Accelerated Immunosenescence and Chronic Kidney Disease

The immunosenescence is a complex and profound remodeling of the immune system during life. It is mainly due to thymic involution and repeated antigenic stimulation. Kidney disease is associated with a decrease in adaptive immunity as evidenced by the decrease in vaccine response and increased susceptibility to infections, similar to those observed in the elderly population.

However, data on aging of the immune system in chronic kidney disease remains incomplete. Furthermore, the determinants of immunosenescence are not also not known. It is possible that "uremic" factors help explain the phenotypic and functional changes of lymphocytes, as antigenic stimuli associated with repeated bio-compatible materials used in dialysis contact.

The purpose of this study is to describe the phenotypes of the immune system of renal and analyze the determinants of these changes.

Inclusion criteria

• Patient able to understand the reason of the study
• Patient not opposed to the conservation of biological samples for scientific research

Exclusion criteria

• Patient suffering from psychotic illness
• Any history of immunosuppressive therapy (except steroids up to 5mg/day)
• History of cancer (except skin cancer) or treated hematological malignancy
• Infectious episode required hospitalization not older 3 months
• Hepatitis B or C infection
• HIV infection, active or inactive
• For dialysis patients: renal failure on dialysis for less than 3 months and/or have benefited from two techniques for renal replacement therapy in the last 6 months